M. Reza Mohammadi, PhD is member of the XOStem Science Advisory Board and received his PhD degree in Materials Science and Engineering with a concentration in exosome therapy. His research demonstrated the cellular and molecular pathways underlying the therapeutic efficacy of exosomes in treating a multiple sclerosis model in rodents. He developed a hybrid biomaterial that regulates the local immune system nearby to cellular implants, protecting the transplanted cells from host immune attack. Prior to his PhD work, Dr. Moammadi was a research scientist at Stanford University where he focused on interactions between nanomaterials and the immune system. .

Published Articles

Mohammadi MR, Rodriguez SM, Luong JC, Li S, Cao R, Alshetaiwi H, Lau H, Davtyan H, Jones MB, Jafari M, Kessenbrock K, Villalta SA, de Vos P, Zhao W, Lakey JRT. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 Jun 3;4(1):685. doi: 10.1038/s42003-021-02229-4. PMID: 34083739; PMCID: PMC8175379. https://pubmed.ncbi.nlm.nih.gov/34083739/

Lau H, Corrales N, Rodriguez S, Park S, Mohammadi M, Li S, Alexander M, Lakey JRT. The effects of necrostatin-1 on the in vitro development and function of young porcine islets over 14-day prolonged tissue culture. Xenotransplantation. 2021 May;28(3):e12667. doi: 10.1111/xen.12667. Epub 2021 Jan 12. PMID: 33438288. https://pubmed.ncbi.nlm.nih.gov/33438288/

Mohammadi M, Luong JC, Rodriguez SM, Cao R, Wheeler AE, Lau H, Li S, Shabestari SK, Chadarevian JP, Alexander M, de Vos P, Zhao W, Lakey JRT. Controlled Release of Stem Cell Secretome Attenuates Inflammatory Response against Implanted Biomaterials. Adv Healthc Mater. 2020 Jun;9(12):e1901874. doi: 10.1002/adhm.201901874. Epub 2020 May 18. PMID: 32419390. https://pubmed.ncbi.nlm.nih.gov/32419390/

Mohammadi MR, Dehkordi-Vakil F, Ricks-Oddie J, Mansfield R, Kashimiri H, Daniels M, Zhao W, Lakey JR. Preferences of Type 1 Diabetic Patients on Devices for Islet Transplantation. Cell Transplant. 2020 Jan-Dec;29:963689720952343. doi: 10.1177/0963689720952343. PMID: 33023311; PMCID: PMC7784499. https://pubmed.ncbi.nlm.nih.gov/33023311/

Lau H, Corrales N, Alexander M, Mohammadi MR, Li S, Smink AM, de Vos P, Lakey JRT. Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function. Xenotransplantation. 2020 Jan;27(1):e12555. doi: 10.1111/xen.12555. Epub 2019 Sep 18. PMID: 31532037. https://pubmed.ncbi.nlm.nih.gov/31532037/

Lau H, Corrales N, Rodriguez S, Luong C, Mohammadi M, Khosrawipour V, Li S, Alexander M, de Vos P, Lakey JRT. Dose-dependent effects of necrostatin-1 supplementation to tissue culture media of young porcine islets. PLoS One. 2020 Dec 7;15(12):e0243506. doi: 10.1371/journal.pone.0243506. PMID: 33284818; PMCID: PMC7721208.  https://pubmed.ncbi.nlm.nih.gov/33284818/

Mohammadi M, Luong JC, Rodriguez SM, Cao R, Wheeler AE, Lau H, Li S, Shabestari SK,

Chadarevian JP, Alexander M, de Vos P, Zhao W, Lakey JRT. Controlled Release of Stem Cell Secretome Attenuates Inflammatory Response against Implanted Biomaterials. Adv Healthc Mater. 2020 Jun;9(12):e1901874. doi: 10.1002/adhm.201901874. Epub 2020 May 18. PMID: 32419390.  https://pubmed.ncbi.nlm.nih.gov/32419390/

Riazifar M, Mohammadi MR, Pone EJ, Yeri A, Lässer C, Segaliny AI, McIntyre LL, Shelke GV, Hutchins E, Hamamoto A, Calle EN, Crescitelli R, Liao W, Pham V, Yin Y, Jayaraman J, Lakey JRT, Walsh CM, Van Keuren-Jensen K, Lotvall J, Zhao W. Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders. ACS Nano. 2019 Jun 25;13(6):6670-6688. doi: 10.1021/acsnano.9b01004.

Epub 2019 May 29. PMID: 31117376; PMCID: PMC6880946. https://pubmed.ncbi.nlm.nih.gov/31117376/

Mohammadi MR, Corbo C, Molinaro R, Lakey JRT. Biohybrid Nanoparticles to Negotiate with Biological Barriers.Small. 2019 Aug;15(34):e1902333. doi: 10.1002/smll.201902333. Epub 2019 Jun 28. PMID: 31250985.  https://pubmed.ncbi.nlm.nih.gov/31250985

Dubnika A, Manoukian MAC, Mohammadi MR, Parekh MB, Gurjarpadhye AA, Inayathullah M, Dubniks V, Lakey JRT, Rajadas J. Cytokines as therapeutic agents and targets in heart disease. Cytokine Growth Factor Rev. 2018 Oct;43:54-68. doi: 10.1016/j.cytogfr.2018.08.003. Epub 2018 Aug 16. PMID: 30170892. https://pubmed.ncbi.nlm.nih.gov/30170892/

Kopan C, Tucker T, Alexander M, Mohammadi MR, Pone EJ, Lakey JRT. Approaches in Immunotherapy, Regenerative Medicine, and Bioengineering for Type 1 Diabetes. Front Immunol. 2018 Jun 12;9:1354. doi: 10.3389/fimmu.2018.01354. PMID: 29963051; PMCID: PMC6011033. https://pubmed.ncbi.nlm.nih.gov/29963051/

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